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The Great Shamokin Path was established by Native Americans thousands of years ago. It follows along the West Branch of hte Susquehanna River and then over to Great Island in Pennsylvania. 
It connected the two largest Indian communities in Pennsylvania, Shamokin and Kittanning and was used by Native Americans for travel into the current Ohio region of America.
During the French and Indian War, it enabled Delaware and Shawnee warriors to quickly travel cross-country in an attempt to recover lands lost to the British in the French and Indian War. 
In 1772, the path was used by John Ettwein and 200 Lenape and Mohican Christians to travel from Friedenshutten to their new village, Friedensstadt in southwestern Pennsylvania.